Endocrine Abstracts

Estetrol (E4) is a natural human steroid, produced exclusively during pregnancy by the fetal liver. Estetrol has been discovered in 1965 by Diczfalusy at the Karolinska Institute in Stockholm.The role of E4 in embryonic physiology and/or human pregnancy is not known. During human pregnancy E4 is detectable from 9 weeks pregnancy onwards. Estetrol reaches the maternal blood circulation via the placenta. Maternal and fetal E4 concentrations increase expone...